Ali Marhon

Hi there, I’m

Ali Marhon

Building from biology.

PharmD student at the Leslie Dan Faculty of Pharmacy, University of Toronto — and data scientist building ML pipelines for translational oncology and cardiovascular genomics.

01

About

Data scientist working at the intersection of machine learning, biology, and clinical pharmacy. Focus: turning raw biological signal — single-cell transcriptomes, molecular graphs, sequence data — into reproducible, statistically defensible insight, held up under end-to-end pipelines and held-out evaluation.

Clinical

19minor ailments

Minor Ailments Assistant · Reg. 256/24

Ontario pharmacist assistant covering the full Reg. 256/24 scope, shipped entirely client-side. UofT PharmD begins Fall 2026 — the clinical arc runs alongside, not in place of, the data-science work.

Machine learning

0.91AUROC

GraphDTI · Drug–Target

Geometric deep-learning drug–target interaction model, held out on unseen BindingDB pairs.

Machine learning

98.3%TCGA held-out

Meridian · Tissue-of-Origin

Calibrated, interpretable tissue-of-origin classifier with conformal abstention on out-of-distribution samples.

Biology

+9.08log2FC IFNG

TAA scRNA-seq · GSE155468

Sex-stratified differential expression in ascending thoracic aortic aneurysm at patient-level hierarchy (n=11).

02

Relevant Experience

  1. 01 Mar 2026 – Jun 2026 clinical Fillware · K&F ordering · blister · cold-chain

    Pharmacy Assistant

    Faircare & CDE Pharmacy · Kitchener ON

    Front-counter and back-of-pharmacy support: helping patients locate over-the-counter products and answering general product questions while referring medication and health-related questions to the pharmacist and safeguarding patient confidentiality. Prescription preparation under pharmacist supervision using Fillware (counting, labelling, and data entry for the pharmacist’s final check). Narcotics and controlled-substance documentation per record-keeping requirements, cytotoxic / hazardous handling with required PPE, compliance (blister) packaging for pharmacist verification, and cold-chain management for insulin and GLP-1 agonists.

    Third-party insurance billing, refill authorizations by fax to prescribers, and inventory ordered from Kohl & Frisch (K&F) — receiving-check for accuracy and expiry monitoring.

    fillware · narcotics · blister packaging · cold-chain · k&f · third-party billing · ppe

  2. 02 Mar 2025 – Mar 2026 1,200+ samples · Compute Canada HPC · AUROC 0.87

    Data Scientist / Bioinformatics Analyst

    Lawson Health Research Institute · Western University affiliate · London ON

    End-to-end RNA-seq and single-cell ML pipelines (STAR, Salmon, DESeq2, Scanpy) for translational oncology. 1,200+ patient samples through Docker-containerized, Snakemake/Airflow-orchestrated, MLflow-tracked stack on Compute Canada HPC. Random-forest oncology classifier (n=480) AUROC 0.87 / PR-AUC 0.71. LIMS-to-warehouse ETL (STARLIMS → PostgreSQL + dbt) eliminated ~12 hrs/wk of manual extraction. Gene-set enrichment (Fisher's, BH-FDR, GSEA). Internal R/Python workshops.

    python · r · scanpy · deseq2 · snakemake · airflow · mlflow · docker · postgres · dbt

  3. 03 M.Sc. thesis NanoString · BCAA + VSMC remodeling

    M.Sc. thesis — Age- & Sex-dependent Profiling of Angiotensin II–Induced Thoracic Aortic Degeneration in Mice

    Pickering Lab · Robarts Research Institute · Western University

    Sex/age-dependent protective mechanisms in murine TAA. In situ aortic measurements, histology, RNA isolation, NanoString nCounter transcriptomics. R pipelines (DE, pathway enrichment, multi-group integration). Found altered BCAA catabolism + VSMC remodeling as protective programs.

    r · nanostring · deseq2 · fgsea · histology · rna-seq

  4. 04 Sept 2019 – Apr 2020 CHARMM36 · 1μs @ 310K / 410K

    Molecular Dynamics of Keap1 R470H — a Cancer-Linked Mutation

    Choy Lab · Department of Biochemistry · Western University

    All-atom MD in GROMACS + CHARMM36 (PDB 2FLU, R470H mutagenesis, MODELLER-repaired). Rg, backbone RMSD, per-residue RMSF, Ramachandran φ/ψ at residue 470 across 1 μs at 310 K and 410 K. Mutant tracks WT at physiological T but explores extra basins under thermal stress.

    gromacs · charmm36 · modeller · molecular dynamics · ramachandran

  5. 05 2019 – 2021 PIPE cloning · SDM · Sanger

    Undergraduate Research Assistant

    Western University · London ON

    Functional analysis of ATAD5. WT + mutant constructs via PIPE cloning, site-directed mutagenesis, Sanger sequencing. Plasmid prep, transformation, colony PCR, midi/miniprep, E. coli culture maintenance.

    molecular biology · pipe cloning · sanger · site-directed mutagenesis · pcr · e. coli

  6. 06 2018 – 2020 clinical Cerner · Kroll · EMR

    Clinical Research Assistant · Cardiovascular

    University Hospital · London Health Sciences Centre · London ON

    Minimally-invasive cardiovascular outcomes study. Patient data collection, DB maintenance with physicians/nurses/PIs. Anonymized visual reports. Recruitment and follow-up. Daily work with Cerner and Kroll pharmacy management alongside clinical pharmacists on medication docs and EMR integration.

    clinical research · cerner · kroll · regulatory compliance · emr

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Projects

Drug Discoverysource ↗

GraphDTI

Geometric deep learning for drug–target interaction prediction. A Graph Isomorphism Network with attentive readout encodes ligands; contrastive pretraining with held-out kinase families. Served behind FastAPI with SHAP-on-graph interpretability.

0.91AUROC · BindingDB
1.2MDTI pairs
SHAPinterpretability

pytorch · pyg · rdkit · fastapi · sagemaker

Oncology MLsource ↗

Meridian CUP origin

Calibrated tissue-of-origin classifier for Cancer of Unknown Primary. A LightGBM ensemble trained on 9,358 TCGA primaries across 25 organ classes, wrapped in temperature scaling + split-conformal prediction — so the model abstains on out-of-distribution metastases instead of overconfidently misclassifying them.

98.3%TCGA held-out accuracy
92.3%MET500 · w/ abstention
25organ classes covered

python · lightgbm · shap · conformal · tcga

Genomicssource ↗

TAA scRNA-seq

Sex-stratified differential expression in human ascending thoracic aortic aneurysm. Pseudobulk DESeq2 with the sex×disease interaction surfaces female-skewed IFN-γ / OXPHOS signatures across SMCs, NK, T, and plasma cells.

n=11GSE155468 cohort
sex×dxinteraction term
5+cell types profiled

r · seurat · deseq2 · harmony · fgsea

Meta-analysissource ↗

Replication study

Cross-cohort replication of sex differences in TAA. Combines scRNA-seq (Li 2020) and snRNA-seq (Chou 2022) via cross-platform integration + random-effects meta-analysis on cohort-level effect sizes.

n=24combined cohorts
platforms integrated
RErandom-effects MA

r · harmony · scvi · metafor · deseq2

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Contact

Let’s talk.

Open to research collaborations, ML / DS opportunities, and conversations about data, biology, or markets. Email is fastest.